Publications

2022

Heyward FD, Liu N, Jacobs C, Ivison R, Machado N, Uner A, Srinivasan H, Patel SJ, Gulko A, Sermersheim T, Orkin SH, Tsai L & Rosen ED. Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects. BioRxiv 2022.01.03.474708, https://doi.org/10.1101/2022.01.03.474708

Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, da Rocha EL, Liu N, Orkin SH, North TE, Daley GQ & Rowe RG. Developmental maturation of the hematopoietic system controlled by a Lin28b-let7-PRC1 axis, BioRxiv 2022.01.05.474696, https://doi.org/10.1101/2022.01.05.474696

Ludwig LS, Lareau CA, Bao EL, Liu N, et al., A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1. Blood accepted.

Patel SJ, Liu N, et al., Hepatic Interferon Regulatory Factor 3 Fuels Gluconeogenesis via PP2A-mediated Inactivation of AMP Kinase. Science Translational Medicine accepted.

2021

Shen Y, Verboon JM, Zhang Y, Liu N, Kim YJ, Marglous S, Nandakumar SK, Voit RA, Fiorini C, Ejaz A, Basak A, Orkin SH, Xu J, Sankaran VG. A unified model of human hemoglobin switching through single-cell genome editing. Nature Communications 2021;12:4991-.

Liu N*, Xu S*, Yao Q, Zhu Q, Kai Y, Hsu J, Sakon P, Pinello L, Yuan G-C, Bauer DE, Orkin SH. Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nature Genetics 2021;53:511-20. (*: co-first author) pdf

BioArt: 专家点评Nat Genetics | 刘楠/许书倩合作揭示全新血红蛋白转换模型,为治愈地中海贫血提供新靶点

2020

Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten G, Cao H, Orkin SH, Zhang MQ & Xu J. Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biology 2020;21:59-

2019

Zhu Q, Liu N, Orkin SH & Yuan G-C. CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biology 2019;20:192-.

Fu H*, Liu N*, Dong Q, Ma C, Yang J, Xiong J, Zhang Z, Qi X, Huang C, Zhu B. SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization. Cell Research 2019;29:254-7. (*: co-first author)

2018

Liu N*, Hargreaves V*, Zhu Q*, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan G-C, Bauer DE, Xu J, Bulyk ML, Orkin SH. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell 2018;173:430-42. (*: co-first author) pdf

Rated exceptional by F1000Prime.

知识分子:一个人老“珠”黄的古老领域,何以焕发新传奇?

2016

Fu W*, Liu N*, Qiao Q, Wang M, Min J, Zhu B, Xu R-M, Yang N. Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase. Journal of Biological Chemistry 2016;291:9173-80. (*: co-first author)

2015

Liu N*, Zhang Z*, Wu H*, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes & Development 2015;29:379-93. (*: co-first author)

Before 2015

Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S, Zhu B. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 2012;337:971-5.

Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B. H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation. Journal of Biological Chemistry 2011;286:7983-9.

Book Chapters

Liu N and Zhu B. Regulation of PRC2 activity. Chapter 10 In Polycomb Group Proteins (pp. 225–258). Edited by Vincenzo Pirrotta. Elsevier, 2017. ISBN: 9780128097373