Heyward FD, Liu N, Jacobs C, Machado NLS, Ivison R, Uner A, Srinivasan H, Patel SJ, Gulko A, Sermersheim T, Tsai L, Rosen ED. AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin’s acute effects. Nature Communications 2024;15(1):4646.

Yang K, Zhu T, Yin J, Zhang Q, Li J, Fan H, Han G, Xu W, Liu N#, Lv X#. The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis. Journal of Genetics and Genomics 2024 in press.


Kai Y, Liu N, Orkin SH, Yuan G-C. Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC. BMC Genomics 2023;24:614.

Xu Z, Wang Y, Sheng K, Rosenthal R, Liu N, Hua X, Zhang T, Chen J, Song M, Lv Y, Zhang S, Huang Y, Wang Z, Cao T, Shen Y, Jiang Y, Yu Y, Chen Y, Guo G, Yin P, Weitz DA, Wang Y. Droplet-based high-throughput single microbe RNA sequencing by smRandom-seq. Nature Communications 2023;14(1):5130.

Liao C, Wang Y, Huang Y, Duan Y, Liang Y, Chen J, Jiang J, Shang K, Zhou C, Gu Y, Liu N, Zeng X, Gao X, Tang Y, Sun J. CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells. Advanced Science 2023, 2207394.


Heyward FD, Liu N, Jacobs C, Ivison R, Machado N, Uner A, Srinivasan H, Patel SJ, Gulko A, Sermersheim T, Orkin SH, Tsai L & Rosen ED. Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects. BioRxiv 2022.01.03.474708,

Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, da Rocha EL, Liu N, Orkin SH, North TE, Daley GQ & Rowe RG. Developmental maturation of the hematopoietic system controlled by a Lin28b-let7-PRC1 axis, Cell Reports 2022;39(1):110587.

Ludwig LS, Lareau CA, Bao EL, Liu N, et al., A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1. Blood 2022;139(16):2534-2546.

Patel SJ, Liu N, et al., Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Science Translational Medicine 2022;14(637):eabh3831.


Shen Y, Verboon JM, Zhang Y, Liu N, Kim YJ, Marglous S, Nandakumar SK, Voit RA, Fiorini C, Ejaz A, Basak A, Orkin SH, Xu J, Sankaran VG. A unified model of human hemoglobin switching through single-cell genome editing. Nature Communications 2021;12:4991-.

Liu N*, Xu S*, Yao Q, Zhu Q, Kai Y, Hsu J, Sakon P, Pinello L, Yuan G-C, Bauer DE, Orkin SH. Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nature Genetics 2021;53:511-20. (*: co-first author) pdf

BioArt: 专家点评Nat Genetics | 刘楠/许书倩合作揭示全新血红蛋白转换模型,为治愈地中海贫血提供新靶点


Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten G, Cao H, Orkin SH, Zhang MQ & Xu J. Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biology 2020;21:59-


Zhu Q, Liu N, Orkin SH & Yuan G-C. CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biology 2019;20:192-.

Fu H*, Liu N*, Dong Q, Ma C, Yang J, Xiong J, Zhang Z, Qi X, Huang C, Zhu B. SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization. Cell Research 2019;29:254-7. (*: co-first author)


Liu N*, Hargreaves V*, Zhu Q*, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan G-C, Bauer DE, Xu J, Bulyk ML, Orkin SH. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell 2018;173:430-42. (*: co-first author) pdf

Rated exceptional by F1000Prime.



Fu W*, Liu N*, Qiao Q, Wang M, Min J, Zhu B, Xu R-M, Yang N. Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase. Journal of Biological Chemistry 2016;291:9173-80. (*: co-first author)


Liu N*, Zhang Z*, Wu H*, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes & Development 2015;29:379-93. (*: co-first author)

Before 2015

Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S, Zhu B. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 2012;337:971-5.

Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B. H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation. Journal of Biological Chemistry 2011;286:7983-9.

Book Chapters

Liu N and Zhu B. Regulation of PRC2 activity. Chapter 10 In Polycomb Group Proteins (pp. 225–258). Edited by Vincenzo Pirrotta. Elsevier, 2017. ISBN: 9780128097373


Library Prep for CUT&RUN with NEBNext® Ultra™ II DNA Library Prep Kit for Illumina® (E7645)